Ontology highlight
ABSTRACT:
SUBMITTER: Dey P
PROVIDER: S-EPMC4444278 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Dey Prasenjit P Velazquez-Villegas Laura A LA Faria Michelle M Turner Anthony A Jonsson Philp P Webb Paul P Williams Cecilia C Gustafsson Jan-Åke JÅ Ström Anders M AM
PloS one 20150526 5
The estrogen receptor (ER) β variant ERβ2 is expressed in aggressive castration-resistant prostate cancer and has been shown to correlate with decreased overall survival. Genome-wide expression analysis after ERβ2 expression in prostate cancer cells revealed that hypoxia was an overrepresented theme. Here we show that ERβ2 interacts with and stabilizes HIF-1α protein in normoxia, thereby inducing a hypoxic gene expression signature. HIF-1α is known to stimulate metastasis by increasing expressio ...[more]