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Bruton tyrosine kinase inhibitors: a promising novel targeted treatment for B cell lymphomas.

ABSTRACT: Constitutive or aberrant signalling of the B cell receptor signalling cascade has been implicated in the propagation and maintenance of a variety of B cell malignancies. Small molecule inhibitors of Bruton tyrosine kinase (BTK), a protein early in this cascade and specifically expressed in B cells, have emerged as a new class of targeted agents. There are several BTK inhibitors, including ONO-WG-307, LFM-A13, dasatinib, CC-292, and PCI-32765 (ibrutinib), in preclinical and/or clinical development of which ibrutinib is currently in phase III trials. Recent clinical data suggest significant activity of ibrutinib as a first in class oral inhibitor of BTK. This review provides an overview of ongoing clinical studies of BTK inhibitors.

SUBMITTER: Aalipour A

PROVIDER: S-EPMC4444436 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature

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Bruton tyrosine kinase inhibitors: a promising novel targeted treatment for B cell lymphomas.

Aalipour Amin A Advani Ranjana H RH

British journal of haematology 20130924 4

Constitutive or aberrant signalling of the B cell receptor signalling cascade has been implicated in the propagation and maintenance of a variety of B cell malignancies. Small molecule inhibitors of Bruton tyrosine kinase (BTK), a protein early in this cascade and specifically expressed in B cells, have emerged as a new class of targeted agents. There are several BTK inhibitors, including ONO-WG-307, LFM-A13, dasatinib, CC-292, and PCI-32765 (ibrutinib), in preclinical and/or clinical developmen ...[more]

PMID: 24111579

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