Identification of six new susceptibility loci for invasive epithelial ovarian cancer.
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ABSTRACT:
SUBMITTER: Kuchenbaecker KB
PROVIDER: S-EPMC4445140 | biostudies-literature | 2015 Feb
REPOSITORIES: biostudies-literature
Publications
Identification of six new susceptibility loci for invasive epithelial ovarian cancer.
Kuchenbaecker Karoline B KB Ramus Susan J SJ Tyrer Jonathan J Lee Andrew A Shen Howard C HC Beesley Jonathan J Lawrenson Kate K McGuffog Lesley L Healey Sue S Lee Janet M JM Spindler Tassja J TJ Lin Yvonne G YG Pejovic Tanja T Bean Yukie Y Li Qiyuan Q Coetzee Simon S Hazelett Dennis D Miron Alexander A Southey Melissa M Terry Mary Beth MB Goldgar David E DE Buys Saundra S SS Janavicius Ramunas R Dorfling Cecilia M CM van Rensburg Elizabeth J EJ Neuhausen Susan L SL Ding Yuan Chun YC Hansen Thomas V O TV Jønson Lars L Gerdes Anne-Marie AM Ejlertsen Bent B Barrowdale Daniel D Dennis Joe J Benitez Javier J Osorio Ana A Garcia Maria Jose MJ Komenaka Ian I Weitzel Jeffrey N JN Ganschow Pamela P Peterlongo Paolo P Bernard Loris L Viel Alessandra A Bonanni Bernardo B Peissel Bernard B Manoukian Siranoush S Radice Paolo P Papi Laura L Ottini Laura L Fostira Florentia F Konstantopoulou Irene I Garber Judy J Frost Debra D Perkins Jo J Platte Radka R Ellis Steve S Godwin Andrew K AK Schmutzler Rita Katharina RK Meindl Alfons A Engel Christoph C Sutter Christian C Sinilnikova Olga M OM Damiola Francesca F Mazoyer Sylvie S Stoppa-Lyonnet Dominique D Claes Kathleen K De Leeneer Kim K Kirk Judy J Rodriguez Gustavo C GC Piedmonte Marion M O'Malley David M DM de la Hoya Miguel M Caldes Trinidad T Aittomäki Kristiina K Nevanlinna Heli H Collée J Margriet JM Rookus Matti A MA Oosterwijk Jan C JC Tihomirova Laima L Tung Nadine N Hamann Ute U Isaccs Claudine C Tischkowitz Marc M Imyanitov Evgeny N EN Caligo Maria A MA Campbell Ian G IG Hogervorst Frans B L FB Olah Edith E Diez Orland O Blanco Ignacio I Brunet Joan J Lazaro Conxi C Pujana Miquel Angel MA Jakubowska Anna A Gronwald Jacek J Lubinski Jan J Sukiennicki Grzegorz G Barkardottir Rosa B RB Plante Marie M Simard Jacques J Soucy Penny P Montagna Marco M Tognazzo Silvia S Teixeira Manuel R MR Pankratz Vernon S VS Wang Xianshu X Lindor Noralane N Szabo Csilla I CI Kauff Noah N Vijai Joseph J Aghajanian Carol A CA Pfeiler Georg G Berger Andreas A Singer Christian F CF Tea Muy-Kheng MK Phelan Catherine M CM Greene Mark H MH Mai Phuong L PL Rennert Gad G Mulligan Anna Marie AM Tchatchou Sandrine S Andrulis Irene L IL Glendon Gord G Toland Amanda Ewart AE Jensen Uffe Birk UB Kruse Torben A TA Thomassen Mads M Bojesen Anders A Zidan Jamal J Friedman Eitan E Laitman Yael Y Soller Maria M Liljegren Annelie A Arver Brita B Einbeigi Zakaria Z Stenmark-Askmalm Marie M Olopade Olufunmilayo I OI Nussbaum Robert L RL Rebbeck Timothy R TR Nathanson Katherine L KL Domchek Susan M SM Lu Karen H KH Karlan Beth Y BY Walsh Christine C Lester Jenny J Hein Alexander A Ekici Arif B AB Beckmann Matthias W MW Fasching Peter A PA Lambrechts Diether D Van Nieuwenhuysen Els E Vergote Ignace I Lambrechts Sandrina S Dicks Ed E Doherty Jennifer A JA Wicklund Kristine G KG Rossing Mary Anne MA Rudolph Anja A Chang-Claude Jenny J Wang-Gohrke Shan S Eilber Ursula U Moysich Kirsten B KB Odunsi Kunle K Sucheston Lara L Lele Shashi S Wilkens Lynne R LR Goodman Marc T MT Thompson Pamela J PJ Shvetsov Yurii B YB Runnebaum Ingo B IB Dürst Matthias M Hillemanns Peter P Dörk Thilo T Antonenkova Natalia N Bogdanova Natalia N Leminen Arto A Pelttari Liisa M LM Butzow Ralf R Modugno Francesmary F Kelley Joseph L JL Edwards Robert P RP Ness Roberta B RB du Bois Andreas A Heitz Florian F Schwaab Ira I Harter Philipp P Matsuo Keitaro K Hosono Satoyo S Orsulic Sandra S Jensen Allan A Kjaer Susanne Kruger SK Hogdall Estrid E Hasmad Hanis Nazihah HN Azmi Mat Adenan Noor MA Teo Soo-Hwang SH Woo Yin-Ling YL Fridley Brooke L BL Goode Ellen L EL Cunningham Julie M JM Vierkant Robert A RA Bruinsma Fiona F Giles Graham G GG Liang Dong D Hildebrandt Michelle A T MA Wu Xifeng X Levine Douglas A DA Bisogna Maria M Berchuck Andrew A Iversen Edwin S ES Schildkraut Joellen M JM Concannon Patrick P Weber Rachel Palmieri RP Cramer Daniel W DW Terry Kathryn L KL Poole Elizabeth M EM Tworoger Shelley S SS Bandera Elisa V EV Orlow Irene I Olson Sara H SH Krakstad Camilla C Salvesen Helga B HB Tangen Ingvild L IL Bjorge Line L van Altena Anne M AM Aben Katja K H KK Kiemeney Lambertus A LA Massuger Leon F A G LF Kellar Melissa M Brooks-Wilson Angela A Kelemen Linda E LE Cook Linda S LS Le Nhu D ND Cybulski Cezary C Yang Hannah H Lissowska Jolanta J Brinton Louise A LA Wentzensen Nicolas N Hogdall Claus C Lundvall Lene L Nedergaard Lotte L Baker Helen H Song Honglin H Eccles Diana D McNeish Ian I Paul James J Carty Karen K Siddiqui Nadeem N Glasspool Rosalind R Whittemore Alice S AS Rothstein Joseph H JH McGuire Valerie V Sieh Weiva W Ji Bu-Tian BT Zheng Wei W Shu Xiao-Ou XO Gao Yu-Tang YT Rosen Barry B Risch Harvey A HA McLaughlin John R JR Narod Steven A SA Monteiro Alvaro N AN Chen Ann A Lin Hui-Yi HY Permuth-Wey Jenny J Sellers Thomas A TA Tsai Ya-Yu YY Chen Zhihua Z Ziogas Argyrios A Anton-Culver Hoda H Gentry-Maharaj Aleksandra A Menon Usha U Harrington Patricia P Lee Alice W AW Wu Anna H AH Pearce Celeste L CL Coetzee Gerry G Pike Malcolm C MC Dansonka-Mieszkowska Agnieszka A Timorek Agnieszka A Rzepecka Iwona K IK Kupryjanczyk Jolanta J Freedman Matt M Noushmehr Houtan H Easton Douglas F DF Offit Kenneth K Couch Fergus J FJ Gayther Simon S Pharoah Paul P PP Antoniou Antonis C AC Chenevix-Trench Georgia G
Nature genetics 20150112 2
Genome-wide association studies (GWAS) have identified 12 epithelial ovarian cancer (EOC) susceptibility alleles. The pattern of association at these loci is consistent in BRCA1 and BRCA2 mutation carriers who are at high risk of EOC. After imputation to 1000 Genomes Project data, we assessed associations of 11 million genetic variants with EOC risk from 15,437 cases unselected for family history and 30,845 controls and from 15,252 BRCA1 mutation carriers and 8,211 BRCA2 mutation carriers (3,096 ...[more]