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Identification of novel epithelial ovarian cancer loci in women of African ancestry.

ABSTRACT: Women of African ancestry have lower incidence of epithelial ovarian cancer (EOC) yet worse survival compared to women of European ancestry. We conducted a genome-wide association study in African ancestry women with 755 EOC cases, including 537 high-grade serous ovarian carcinomas (HGSOC) and 1,235 controls. We identified four novel loci with suggestive evidence of association with EOC (p?

SUBMITTER: Manichaikul A 

PROVIDER: S-EPMC7523187 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature

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Identification of novel epithelial ovarian cancer loci in women of African ancestry.

Manichaikul Ani A   Peres Lauren C LC   Wang Xin-Qun XQ   Barnard Mollie E ME   Chyn Deanna D   Sheng Xin X   Du Zhaohui Z   Tyrer Jonathan J   Dennis Joseph J   Schwartz Ann G AG   Cote Michele L ML   Peters Edward E   Moorman Patricia G PG   Bondy Melissa M   Barnholtz-Sloan Jill S JS   Terry Paul P   Alberg Anthony J AJ   Bandera Elisa V EV   Funkhouser Ellen E   Wu Anna H AH   Pearce Celeste Leigh CL   Pike Malcom M   Setiawan Veronica Wendy VW   Haiman Christopher A CA   Palmer Julie R JR   LeMarchand Loic L   Wilkens Lynne R LR   Berchuck Andrew A   Doherty Jennifer A JA   Modugno Francesmary F   Ness Roberta R   Moysich Kirsten K   Karlan Beth Y BY   Whittemore Alice S AS   McGuire Valerie V   Sieh Weiva W   Lawrenson Kate K   Gayther Simon S   Sellers Thomas A TA   Pharoah Paul P   Schildkraut Joellen M JM  

International journal of cancer 20191008 11

Women of African ancestry have lower incidence of epithelial ovarian cancer (EOC) yet worse survival compared to women of European ancestry. We conducted a genome-wide association study in African ancestry women with 755 EOC cases, including 537 high-grade serous ovarian carcinomas (HGSOC) and 1,235 controls. We identified four novel loci with suggestive evidence of association with EOC (p < 1 × 10<sup>-6</sup> ), including rs4525119 (intronic to AKR1C3), rs7643459 (intronic to LOC101927394), rs  ...[more]

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