Ontology highlight
ABSTRACT:
SUBMITTER: Manichaikul A
PROVIDER: S-EPMC7523187 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Manichaikul Ani A Peres Lauren C LC Wang Xin-Qun XQ Barnard Mollie E ME Chyn Deanna D Sheng Xin X Du Zhaohui Z Tyrer Jonathan J Dennis Joseph J Schwartz Ann G AG Cote Michele L ML Peters Edward E Moorman Patricia G PG Bondy Melissa M Barnholtz-Sloan Jill S JS Terry Paul P Alberg Anthony J AJ Bandera Elisa V EV Funkhouser Ellen E Wu Anna H AH Pearce Celeste Leigh CL Pike Malcom M Setiawan Veronica Wendy VW Haiman Christopher A CA Palmer Julie R JR LeMarchand Loic L Wilkens Lynne R LR Berchuck Andrew A Doherty Jennifer A JA Modugno Francesmary F Ness Roberta R Moysich Kirsten K Karlan Beth Y BY Whittemore Alice S AS McGuire Valerie V Sieh Weiva W Lawrenson Kate K Gayther Simon S Sellers Thomas A TA Pharoah Paul P Schildkraut Joellen M JM
International journal of cancer 20191008 11
Women of African ancestry have lower incidence of epithelial ovarian cancer (EOC) yet worse survival compared to women of European ancestry. We conducted a genome-wide association study in African ancestry women with 755 EOC cases, including 537 high-grade serous ovarian carcinomas (HGSOC) and 1,235 controls. We identified four novel loci with suggestive evidence of association with EOC (p < 1 × 10<sup>-6</sup> ), including rs4525119 (intronic to AKR1C3), rs7643459 (intronic to LOC101927394), rs ...[more]