Ontology highlight
ABSTRACT:
SUBMITTER: Seeman E
PROVIDER: S-EPMC4445722 | biostudies-literature | 2010 Aug
REPOSITORIES: biostudies-literature
Seeman Ego E Delmas Pierre D PD Hanley David A DA Sellmeyer Deborah D Cheung Angela M AM Shane Elizabeth E Kearns Ann A Thomas Thierry T Boyd Steven K SK Boutroy Stephanie S Bogado Cesar C Majumdar Sharmila S Fan Michelle M Libanati Cesar C Zanchetta Jose J
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20100801 8
The intensity of bone remodeling is a critical determinant of the decay of cortical and trabecular microstructure after menopause. Denosumab suppresses remodeling more than alendronate, leading to greater gains in areal bone mineral density (aBMD). These greater gains may reflect differing effects of each drug on bone microarchitecture and strength. In a phase 2 double-blind pilot study, 247 postmenopausal women were randomized to denosumab (60 mg subcutaneous 6 monthly), alendronate (70 mg oral ...[more]