Ontology highlight
ABSTRACT:
SUBMITTER: Anosova I
PROVIDER: S-EPMC4446428 | biostudies-literature | 2015 May
REPOSITORIES: biostudies-literature
Anosova Irina I Melnik Svitlana S Tripsianes Konstantinos K Kateb Fatiha F Grummt Ingrid I Sattler Michael M
Nucleic acids research 20150427 10
The chromatin remodeling complex NoRC, comprising the subunits SNF2h and TIP5/BAZ2A, mediates heterochromatin formation at major clusters of repetitive elements, including rRNA genes, centromeres and telomeres. Association with chromatin requires the interaction of the TAM (TIP5/ARBP/MBD) domain of TIP5 with noncoding RNA, which targets NoRC to specific genomic loci. Here, we show that the NMR structure of the TAM domain of TIP5 resembles the fold of the MBD domain, found in methyl-CpG binding p ...[more]