RNA-mediated epigenetic regulation of gene expression.
Ontology highlight
ABSTRACT:
SUBMITTER: Holoch D
PROVIDER: S-EPMC4376354 | biostudies-literature | 2015 Feb
REPOSITORIES: biostudies-literature
Publications
RNA-mediated epigenetic regulation of gene expression.
Holoch Daniel D Moazed Danesh D
Nature reviews. Genetics 20150102 2
Diverse classes of RNA, ranging from small to long non-coding RNAs, have emerged as key regulators of gene expression, genome stability and defence against foreign genetic elements. Small RNAs modify chromatin structure and silence transcription by guiding Argonaute-containing complexes to complementary nascent RNA scaffolds and then mediating the recruitment of histone and DNA methyltransferases. In addition, recent advances suggest that chromatin-associated long non-coding RNA scaffolds also r ...[more]
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