Ontology highlight
ABSTRACT:
SUBMITTER: Martin JA
PROVIDER: S-EPMC4446497 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Martin Jennifer A JA Mirau Peter A PA Chushak Yaroslav Y Chávez Jorge L JL Naik Rajesh R RR Hagen Joshua A JA Kelley-Loughnane Nancy N
Journal of analytical methods in chemistry 20150514
A method for identifying an aptamer in a single round was developed using custom DNA microarrays containing computationally derived patterned libraries incorporating no information on the sequences of previously reported thrombin binding aptamers. The DNA library was specifically designed to increase the probability of binding by enhancing structural complexity in a sequence-space confined environment, much like generating lead compounds in a combinatorial drug screening library. The sequence de ...[more]