Ontology highlight
ABSTRACT:
SUBMITTER: Bae H
PROVIDER: S-EPMC4446790 | biostudies-literature | 2015 Mar
REPOSITORIES: biostudies-literature
Bae Harold H Perls Thomas T Steinberg Martin M Sebastiani Paola P
Bayesian analysis 20150301 1
We present a coherent Bayesian framework for selection of the most likely model from the five genetic models (genotypic, additive, dominant, co-dominant, and recessive) commonly used in genetic association studies. The approach uses a polynomial parameterization of genetic data to simultaneously fit the five models and save computations. We provide a closed-form expression of the marginal likelihood for normally distributed data, and evaluate the performance of the proposed method and existing m ...[more]