Ontology highlight
ABSTRACT:
SUBMITTER: Venkatesh HS
PROVIDER: S-EPMC4447122 | biostudies-literature | 2015 May
REPOSITORIES: biostudies-literature
Venkatesh Humsa S HS Johung Tessa B TB Caretti Viola V Noll Alyssa A Tang Yujie Y Nagaraja Surya S Gibson Erin M EM Mount Christopher W CW Polepalli Jai J Mitra Siddhartha S SS Woo Pamelyn J PJ Malenka Robert C RC Vogel Hannes H Bredel Markus M Mallick Parag P Monje Michelle M
Cell 20150423 4
Active neurons exert a mitogenic effect on normal neural precursor and oligodendroglial precursor cells, the putative cellular origins of high-grade glioma (HGG). By using optogenetic control of cortical neuronal activity in a patient-derived pediatric glioblastoma xenograft model, we demonstrate that active neurons similarly promote HGG proliferation and growth in vivo. Conditioned medium from optogenetically stimulated cortical slices promoted proliferation of pediatric and adult patient-deriv ...[more]