Ontology highlight
ABSTRACT:
SUBMITTER: El Helou J
PROVIDER: S-EPMC3683757 | biostudies-literature | 2013 Jun
REPOSITORIES: biostudies-literature
El Helou Janine J Bélanger-Nelson Erika E Freyburger Marlène M Dorsaz Stéphane S Curie Thomas T La Spada Francesco F Gaudreault Pierre-Olivier PO Beaumont Éric É Pouliot Philippe P Lesage Frédéric F Frank Marcos G MG Franken Paul P Mongrain Valérie V
Proceedings of the National Academy of Sciences of the United States of America 20130528 24
Maintaining wakefulness is associated with a progressive increase in the need for sleep. This phenomenon has been linked to changes in synaptic function. The synaptic adhesion molecule Neuroligin-1 (NLG1) controls the activity and synaptic localization of N-methyl-d-aspartate receptors, which activity is impaired by prolonged wakefulness. We here highlight that this pathway may underlie both the adverse effects of sleep loss on cognition and the subsequent changes in cortical synchrony. We found ...[more]