Ontology highlight
ABSTRACT:
SUBMITTER: Lipton JO
PROVIDER: S-EPMC4447213 | biostudies-literature | 2015 May
REPOSITORIES: biostudies-literature
Lipton Jonathan O JO Yuan Elizabeth D ED Boyle Lara M LM Ebrahimi-Fakhari Darius D Kwiatkowski Erica E Nathan Ashwin A Güttler Thomas T Davis Fred F Asara John M JM Sahin Mustafa M
Cell 20150514 5
The circadian timing system synchronizes cellular function by coordinating rhythmic transcription via a transcription-translational feedback loop. How the circadian system regulates gene expression at the translational level remains a mystery. Here, we show that the key circadian transcription factor BMAL1 associates with the translational machinery in the cytosol and promotes protein synthesis. The mTOR-effector kinase, ribosomal S6 protein kinase 1 (S6K1), an important regulator of translation ...[more]