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Sleep promotes branch-specific formation of dendritic spines after learning.

ABSTRACT: How sleep helps learning and memory remains unknown. We report in mouse motor cortex that sleep after motor learning promotes the formation of postsynaptic dendritic spines on a subset of branches of individual layer V pyramidal neurons. New spines are formed on different sets of dendritic branches in response to different learning tasks and are protected from being eliminated when multiple tasks are learned. Neurons activated during learning of a motor task are reactivated during subsequent non-rapid eye movement sleep, and disrupting this neuronal reactivation prevents branch-specific spine formation. These findings indicate that sleep has a key role in promoting learning-dependent synapse formation and maintenance on selected dendritic branches, which contribute to memory storage.

SUBMITTER: Yang G

PROVIDER: S-EPMC4447313 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature

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Sleep promotes branch-specific formation of dendritic spines after learning.

Yang Guang G Lai Cora Sau Wan CS Cichon Joseph J Ma Lei L Li Wei W Gan Wen-Biao WB

Science (New York, N.Y.) 20140601 6188

How sleep helps learning and memory remains unknown. We report in mouse motor cortex that sleep after motor learning promotes the formation of postsynaptic dendritic spines on a subset of branches of individual layer V pyramidal neurons. New spines are formed on different sets of dendritic branches in response to different learning tasks and are protected from being eliminated when multiple tasks are learned. Neurons activated during learning of a motor task are reactivated during subsequent non ...[more]

PMID: 24904169

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