Ontology highlight
ABSTRACT:
SUBMITTER: Padmanabhan P
PROVIDER: S-EPMC6592683 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Padmanabhan Pranesh P Martínez-Mármol Ramón R Xia Di D Götz Jürgen J Meunier Frédéric A FA
eLife 20190625
The Src kinase Fyn plays critical roles in memory formation and Alzheimer's disease. Its targeting to neuronal dendrites is regulated by Tau via an unknown mechanism. As nanoclustering is essential for efficient signaling, we used single-molecule tracking to characterize the nanoscale distribution of Fyn in mouse hippocampal neurons, and manipulated the expression of Tau to test whether it controls Fyn nanoscale organization. We found that dendritic Fyn exhibits at least three distinct motion st ...[more]