Unknown

Dataset Information

0

MicroRNA-155 Reinforces HIV Latency.


ABSTRACT: The presence of a small number of infected but transcriptionally dormant cells currently thwarts a cure for the more than 35 million individuals infected with HIV. Reactivation of these latently infected cells may result in three fates: 1) cell death due to a viral cytopathic effect, 2) cell death due to immune clearance, or 3) a retreat into latency. Uncovering the dynamics of HIV gene expression and silencing in the latent reservoir will be crucial for developing an HIV-1 cure. Here we identify and characterize an intracellular circuit involving TRIM32, an HIV activator, and miR-155, a microRNA that may promote a return to latency in these transiently activated reservoir cells. Notably, we demonstrate that TRIM32, an E3 ubiquitin ligase, promotes reactivation from latency by directly modifying I?B?, leading to a novel mechanism of NF-?B induction not involving I?B kinase activation.

SUBMITTER: Ruelas DS 

PROVIDER: S-EPMC4447952 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature

altmetric image

Publications


The presence of a small number of infected but transcriptionally dormant cells currently thwarts a cure for the more than 35 million individuals infected with HIV. Reactivation of these latently infected cells may result in three fates: 1) cell death due to a viral cytopathic effect, 2) cell death due to immune clearance, or 3) a retreat into latency. Uncovering the dynamics of HIV gene expression and silencing in the latent reservoir will be crucial for developing an HIV-1 cure. Here we identif  ...[more]

Similar Datasets

| S-EPMC3064319 | biostudies-literature
| S-EPMC4418834 | biostudies-literature
| S-EPMC6950696 | biostudies-literature
| S-EPMC3167080 | biostudies-literature
| S-EPMC4395878 | biostudies-literature
| S-EPMC3501198 | biostudies-literature
| S-EPMC5697837 | biostudies-literature
| S-EPMC8907217 | biostudies-literature
| S-EPMC3915901 | biostudies-literature
| S-EPMC5354304 | biostudies-literature