Ontology highlight
ABSTRACT:
SUBMITTER: Shibata C
PROVIDER: S-EPMC4448951 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Shibata Chikako C Otsuka Motoyuki M Kishikawa Takahiro T Yoshikawa Takeshi T Ohno Motoko M Takata Akemi A Koike Kazuhiko K
Molecular and cellular therapies 20131213
Expanding knowledge about the crucial roles of microRNAs (miRNAs) in human diseases has led to the idea that miRNAs may be novel, promising therapeutic targets against various pathological conditions. The recent success of a human clinical trial using anti-miR-122 oligonucleotides against chronic hepatitis C virus has paved the way for this approach. In this review, we summarize briefly the current status of clinical trials of miRNA-targeting therapy and several representative preclinical trials ...[more]