Ontology highlight
ABSTRACT:
SUBMITTER: Crocker J
PROVIDER: S-EPMC4449256 | biostudies-literature | 2015 Jan
REPOSITORIES: biostudies-literature
Crocker Justin J Abe Namiko N Rinaldi Lucrezia L McGregor Alistair P AP Frankel Nicolás N Wang Shu S Alsawadi Ahmad A Valenti Philippe P Plaza Serge S Payre François F Mann Richard S RS Stern David L DL
Cell 20141231 1-2
In animals, Hox transcription factors define regional identity in distinct anatomical domains. How Hox genes encode this specificity is a paradox, because different Hox proteins bind with high affinity in vitro to similar DNA sequences. Here, we demonstrate that the Hox protein Ultrabithorax (Ubx) in complex with its cofactor Extradenticle (Exd) bound specifically to clusters of very low affinity sites in enhancers of the shavenbaby gene of Drosophila. These low affinity sites conferred specific ...[more]