Ontology highlight
ABSTRACT:
SUBMITTER: Slattery M
PROVIDER: S-EPMC3319069 | biostudies-literature | 2011 Dec
REPOSITORIES: biostudies-literature
Slattery Matthew M Riley Todd T Liu Peng P Abe Namiko N Gomez-Alcala Pilar P Dror Iris I Zhou Tianyin T Rohs Remo R Honig Barry B Bussemaker Harmen J HJ Mann Richard S RS
Cell 20111201 6
Members of transcription factor families typically have similar DNA binding specificities yet execute unique functions in vivo. Transcription factors often bind DNA as multiprotein complexes, raising the possibility that complex formation might modify their DNA binding specificities. To test this hypothesis, we developed an experimental and computational platform, SELEX-seq, that can be used to determine the relative affinities to any DNA sequence for any transcription factor complex. Applying t ...[more]