Ontology highlight
ABSTRACT:
SUBMITTER: Kage F
PROVIDER: S-EPMC5575334 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Kage Frieda F Steffen Anika A Ellinger Adolf A Ranftler Carmen C Gehre Christian C Brakebusch Cord C Pavelka Margit M Stradal Theresia T Rottner Klemens K
Scientific reports 20170829 1
The Rho-family small GTPase Cdc42 localizes at plasma membrane and Golgi complex and aside from protrusion and migration operates in vesicle trafficking, endo- and exocytosis as well as establishment and/or maintenance of cell polarity. The formin family members FMNL2 and -3 are actin assembly factors established to regulate cell edge protrusion during migration and invasion. Here we report these formins to additionally accumulate and function at the Golgi apparatus. As opposed to lamellipodia, ...[more]