Ontology highlight
ABSTRACT:
SUBMITTER: Andrews CD
PROVIDER: S-EPMC4449736 | biostudies-literature | 2015 Jan
REPOSITORIES: biostudies-literature
Andrews Chasity D CD Yueh Yun Lan YL Spreen William R WR St Bernard Leslie L Boente-Carrera Mar M Rodriguez Kristina K Gettie Agegnehu A Russell-Lodrigue Kasi K Blanchard James J Ford Susan S Mohri Hiroshi H Cheng-Mayer Cecilia C Hong Zhi Z Ho David D DD Markowitz Martin M
Science translational medicine 20150101 270
Long-acting GSK1265744 (GSK744 LA) is a strand transfer inhibitor of the HIV/SIV (simian immunodeficiency virus) integrase and was shown to be an effective preexposure prophylaxis (PrEP) agent in a low-dose intrarectal SHIV (simian-human immunodeficiency virus) rhesus macaque challenge model. We examined the pharmacokinetics and efficacy of GSK744 LA as PrEP against repeat high-dose intravaginal SHIV challenge in female rhesus macaques treated with Depo-Provera (depot medroxyprogesterone acetate ...[more]