Ontology highlight
ABSTRACT:
SUBMITTER: Hessell AJ
PROVIDER: S-EPMC4334439 | biostudies-literature | 2009 Aug
REPOSITORIES: biostudies-literature
Hessell Ann J AJ Poignard Pascal P Hunter Meredith M Hangartner Lars L Tehrani David M DM Bleeker Wim K WK Parren Paul W H I PW Marx Preston A PA Burton Dennis R DR
Nature medicine 20090607 8
Neutralizing antibodies are thought to be crucial for HIV vaccine protection, but studies in animal models suggest that high antibody concentrations are required. This is a major potential hurdle for vaccine design. However, these studies typically apply a large virus inoculum to ensure infection in control animals in single-challenge experiments. In contrast, most human infection via sexual encounter probably involves repeated exposures to much lower doses of virus. Therefore, animal studies ma ...[more]