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IFN-? resolves inflammation via suppression of neutrophil infiltration and IL-1? production.


ABSTRACT: The most studied biological role of type III interferons (IFNs) has so far been their antiviral activity, but their role in autoimmune and inflammatory diseases remains largely unexplored. Here, we show that treatment with IFN-?2/IL-28A completely halts and reverses the development of collagen-induced arthritis (CIA) and discover cellular and molecular mechanisms of IL-28A antiinflammatory function. We demonstrate that treatment with IL-28A dramatically reduces numbers of proinflammatory IL-17-producing Th17 and ?? T cells in the joints and inguinal lymph nodes, without affecting T cell proliferative responses or levels of anticollagen antibodies. IL-28A exerts its antiinflammatory effect by restricting recruitment of IL-1b-expressing neutrophils, which are important for amplification of inflammation. We identify neutrophils as cells expressing high levels of IFN-? receptor 1 (IFNLR1)-IL-28 receptor ? (IL28RA) and targeted by IL-28A. Our data highlight neutrophils as contributors to the pathogenesis of autoimmune arthritis and present IFN-?s or agonists of IFNLR1-IL28RA as putative new therapeutics for neutrophil-driven inflammation.

SUBMITTER: Blazek K 

PROVIDER: S-EPMC4451128 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature

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IFN-λ resolves inflammation via suppression of neutrophil infiltration and IL-1β production.

Blazek Katrina K   Eames Hayley L HL   Weiss Miriam M   Byrne Adam J AJ   Perocheau Dany D   Pease James E JE   Doyle Sean S   McCann Fiona F   Williams Richard O RO   Udalova Irina A IA  

The Journal of experimental medicine 20150504 6


The most studied biological role of type III interferons (IFNs) has so far been their antiviral activity, but their role in autoimmune and inflammatory diseases remains largely unexplored. Here, we show that treatment with IFN-λ2/IL-28A completely halts and reverses the development of collagen-induced arthritis (CIA) and discover cellular and molecular mechanisms of IL-28A antiinflammatory function. We demonstrate that treatment with IL-28A dramatically reduces numbers of proinflammatory IL-17-p  ...[more]

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