Ontology highlight
ABSTRACT:
SUBMITTER: McLoughlin RM
PROVIDER: S-EPMC1172246 | biostudies-literature | 2005 Jul
REPOSITORIES: biostudies-literature
McLoughlin Rachel M RM Jenkins Brendan J BJ Grail Dianne D Williams Anwen S AS Fielding Ceri A CA Parker Clare R CR Ernst Matthias M Topley Nicholas N Jones Simon A SA
Proceedings of the National Academy of Sciences of the United States of America 20050623 27
Interleukin (IL)-6 signaling through its soluble receptor (IL-6 transsignaling) directs transition between innate and acquired immune responses by orchestrating the chemokine-directed attraction and apoptotic clearance of leukocytes. Through analysis of mononuclear cell infiltration in WT and IL-6-deficient mice during peritoneal inflammation, we now report that IL-6 selectively governs T cell infiltration by regulating chemokine secretion (CXCL10, CCL4, CCL5, CCL11, and CCL17) and chemokine rec ...[more]