Ontology highlight
ABSTRACT:
SUBMITTER: Radu M
PROVIDER: S-EPMC4628059 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
Radu Maria M Lyle Karen K Hoeflich Klaus P KP Villamar-Cruz Olga O Koeppen Hartmut H Chernoff Jonathan J
Molecular and cellular biology 20150921 23
p21-activated kinases (Paks) have been shown to regulate cytoskeleton rearrangements, cell proliferation, attachment, and migration in a variety of cellular contexts, including endothelial cells. However, the role of endothelial Pak in embryo development has not been reported, and currently, there is no consensus on the endothelial function of individual Pak isoforms, in particular p21-activated kinase 2 (Pak2), the main Pak isoform expressed in endothelial cells. In this work, we employ genetic ...[more]