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The transcription factor Bcl11b is specifically expressed in group 2 innate lymphoid cells and is essential for their development.


ABSTRACT: Group 2 innate lymphoid cells (ILCs), or ILC2s, are a subset of recently identified ILCs, which play important roles in innate immunity by producing type 2 effector cytokines. Several transcription factors have been found to have critical functions in the development of both ILC2s and T cells. We report here that Bcl11b, a transcription factor essential in T cell lineage commitment and maintenance, is specifically expressed in progenitors committed to the ILC2 lineage and is required for ILC2 development. The Bcl11b gene is expressed in ?28% of ILC progenitors (ILCPs; common helper innate lymphoid progenitors or ILCPs expressing either ID2 or promyelocytic leukemia zinc finger, respectively). Both in vitro and in vivo, these Bcl11b-expressing early ILCPs generate only ILC2s. Inactivation of Bcl11b causes a complete loss of ILC2 development from hematopoietic progenitors, which is confirmed upon immune challenge with either papain administration or influenza virus infection.

SUBMITTER: Yu Y 

PROVIDER: S-EPMC4451136 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature

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The transcription factor Bcl11b is specifically expressed in group 2 innate lymphoid cells and is essential for their development.

Yu Yong Y   Wang Cui C   Clare Simon S   Wang Juexuan J   Lee Song-Choon SC   Brandt Cordelia C   Burke Shannon S   Lu Liming L   He Daqian D   Jenkins Nancy A NA   Copeland Neal G NG   Dougan Gordon G   Liu Pentao P  

The Journal of experimental medicine 20150511 6


Group 2 innate lymphoid cells (ILCs), or ILC2s, are a subset of recently identified ILCs, which play important roles in innate immunity by producing type 2 effector cytokines. Several transcription factors have been found to have critical functions in the development of both ILC2s and T cells. We report here that Bcl11b, a transcription factor essential in T cell lineage commitment and maintenance, is specifically expressed in progenitors committed to the ILC2 lineage and is required for ILC2 de  ...[more]

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