Ontology highlight
ABSTRACT:
SUBMITTER: Levine JH
PROVIDER: S-EPMC4451454 | biostudies-literature | 2014 Oct
REPOSITORIES: biostudies-literature
Levine Joe H JH Elowitz Michael B MB
Current biology : CB 20141021 20
Cellular 'timers' provide an important function in living cells. Timers help cells defer their responses to stimuli, often for time intervals extending over multiple cell cycles (Figure 1A, left). For example, mammalian oligodendrocyte precursors typically proliferate for ∼ 7 divisions before differentiating during neural development. The bacterium Bacillus subtilis can respond to sudden nutrient limitation by transforming into a dormant spore after ∼ 5 cell cycles. Timers can balance proliferat ...[more]