Ontology highlight
ABSTRACT:
SUBMITTER: Elengoe A
PROVIDER: S-EPMC4451777 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Elengoe Asita A Naser Mohammed Abu MA Hamdan Salehhuddin S Hamdan Salehhuddin S
International journal of genomics 20150518
Currently, protein interaction of Homo sapiens nucleotide binding domain (NBD) of heat shock 70 kDa protein (PDB: 1HJO) with p53 motif remains to be elucidated. The NBD-p53 motif complex enhances the p53 stabilization, thereby increasing the tumor suppression activity in cancer treatment. Therefore, we identified the interaction between NBD and p53 using STRING version 9.1 program. Then, we modeled the three-dimensional structure of p53 motif through homology modeling and determined the binding ...[more]