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Somatostatin cells regulate sensory response fidelity via subtractive inhibition in olfactory cortex.

ABSTRACT: Diverse types of local GABAergic interneurons shape the cortical representation of sensory information. Here we show how somatostatin-expressing interneurons (SOM cells) contribute to odor coding in mouse olfactory cortex. We find that odor-tuned SOM cells regulate principal cells through a purely subtractive operation that is independent of odor identity or intensity. This operation enhances the salience of odor-evoked activity without changing cortical odor tuning. SOM cells inhibit both principal cells and fast-spiking interneurons, indicating that subtractive inhibition reflects the interplay of multiple classes of interneurons.

SUBMITTER: Sturgill JF

PROVIDER: S-EPMC4452122 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature

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Somatostatin cells regulate sensory response fidelity via subtractive inhibition in olfactory cortex.

Sturgill James F JF Isaacson Jeffry S JS

Nature neuroscience 20150309 4

Diverse types of local GABAergic interneurons shape the cortical representation of sensory information. Here we show how somatostatin-expressing interneurons (SOM cells) contribute to odor coding in mouse olfactory cortex. We find that odor-tuned SOM cells regulate principal cells through a purely subtractive operation that is independent of odor identity or intensity. This operation enhances the salience of odor-evoked activity without changing cortical odor tuning. SOM cells inhibit both princ ...[more]

PMID: 25751531

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