Cardiac biomarkers and health-related quality of life in new hemodialysis patients without symptomatic cardiac disease.

ABSTRACT: BACKGROUND:Health Related Quality of Life (HRQOL) is impaired in hemodialysis patients and cardiac biomarkers are elevated, but their relationship is uncertain. OBJECTIVES:To determine whether the cardiac biomarkers, troponin T and N terminal pro-B type natriuretic peptide (NT-proBNP), predict deterioration in the physical domains of HRQOL. DESIGN:A prospective cohort study of patients in a randomized controlled clinical trial of correction of anemia with erythropoietin. SETTING:Multiple hemodialysis centers located throughout Canada and Europe. PARTICIPANTS:Patients who started maintenance hemodialysis within the previous 3-18 months, with no clinical evidence or prior history of symptomatic cardiac failure or ischemic heart disease, and left ventricular volume < 100 ml/m(2). MEASUREMENTS

SUBMITTER: Williams CE 

PROVIDER: S-EPMC4452142 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature