Genome-Wide Association Study of Serum Creatinine Levels during Vancomycin Therapy.
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ABSTRACT:
SUBMITTER: Van Driest SL
PROVIDER: S-EPMC4452656 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Publications
Genome-Wide Association Study of Serum Creatinine Levels during Vancomycin Therapy.
Van Driest Sara L SL McGregor Tracy L TL Velez Edwards Digna R DR Saville Ben R BR Kitchner Terrie E TE Hebbring Scott J SJ Brilliant Murray M Jouni Hayan H Kullo Iftikhar J IJ Creech C Buddy CB Kannankeril Prince J PJ Vear Susan I SI Brothers Kyle B KB Bowton Erica A EA Shaffer Christian M CM Patel Neelam N Delaney Jessica T JT Bradford Yuki Y Wilson Sarah S Olson Lana M LM Crawford Dana C DC Potts Amy L AL Ho Richard H RH Roden Dan M DM Denny Josh C JC
PloS one 20150601 6
Vancomycin, a commonly used antibiotic, can be nephrotoxic. Known risk factors such as age, creatinine clearance, vancomycin dose / dosing interval, and concurrent nephrotoxic medications fail to accurately predict nephrotoxicity. To identify potential genomic risk factors, we performed a genome-wide association study (GWAS) of serum creatinine levels while on vancomycin in 489 European American individuals and validated findings in three independent cohorts totaling 439 European American indivi ...[more]
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