Ontology highlight
ABSTRACT:
SUBMITTER: Van Driest SL
PROVIDER: S-EPMC4452656 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
PloS one 20150601 6
Vancomycin, a commonly used antibiotic, can be nephrotoxic. Known risk factors such as age, creatinine clearance, vancomycin dose / dosing interval, and concurrent nephrotoxic medications fail to accurately predict nephrotoxicity. To identify potential genomic risk factors, we performed a genome-wide association study (GWAS) of serum creatinine levels while on vancomycin in 489 European American individuals and validated findings in three independent cohorts totaling 439 European American indivi ...[more]