Ontology highlight
ABSTRACT:
SUBMITTER: Fedorenko IV
PROVIDER: S-EPMC4453440 | biostudies-literature | 2015 Jan
REPOSITORIES: biostudies-literature
Fedorenko I V IV Gibney G T GT Sondak V K VK Smalley K S M KS Smalley K S M KS
British journal of cancer 20140902 2
In recent years, melanoma has become a poster-child for the development of oncogene-directed targeted therapies. This approach, which has been exemplified by the development of small-molecule BRAF inhibitors and the BRAF/MEK inhibitor combination for BRAF-mutant melanoma, has brought new hope to patients. Despite these successes, treatment failure seems near inevitable in the majority of cases—even in individuals treated with the BRAF/MEK inhibitor doublet. In the current review, we discuss the ...[more]