Ontology highlight
ABSTRACT:
SUBMITTER: Inoue A
PROVIDER: S-EPMC4453443 | biostudies-literature | 2015 Jan
REPOSITORIES: biostudies-literature
Inoue A A Okamoto K K Fujino Y Y Nakagawa T T Muguruma N N Sannomiya K K Mitsui Y Y Takaoka T T Kitamura S S Miyamoto H H Okahisa T T Fujimori T T Imoto I I Takayama T T
British journal of cancer 20141014 2
<h4>Background</h4>Sessile serrated adenomas/polyps (SSA/Ps) are a putative precursor of colon cancer with microsatellite instability (MSI). However, the developmental mechanism of SSA/P remains unknown. We performed genetic analysis and genome-wide DNA methylation analysis in aberrant crypt foci (ACF), SSA/P, and cancer in SSA/P specimens to show a close association between ACF and the SSA/P-cancer sequence. We also evaluated the prevalence and number of ACF in SSA/P patients.<h4>Methods</h4>AC ...[more]