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Optimal control based seizure abatement using patient derived connectivity.

ABSTRACT: Epilepsy is a neurological disorder in which patients have recurrent seizures. Seizures occur in conjunction with abnormal electrical brain activity which can be recorded by the electroencephalogram (EEG). Often, this abnormal brain activity consists of high amplitude regular spike-wave oscillations as opposed to low amplitude irregular oscillations in the non-seizure state. Active brain stimulation has been proposed as a method to terminate seizures prematurely, however, a general and widely-applicable approach to optimal stimulation protocols is still lacking. In this study we use a computational model of epileptic spike-wave dynamics to evaluate the effectiveness of a pseudospectral method to simulated seizure abatement. We incorporate brain connectivity derived from magnetic resonance imaging of a subject with idiopathic generalized epilepsy. We find that the pseudospectral method can successfully generate time-varying stimuli that abate simulated seizures, even when including heterogeneous patient specific brain connectivity. The strength of the stimulus required varies in different brain areas. Our results suggest that seizure abatement, modeled as an optimal control problem and solved with the pseudospectral method, offers an attractive approach to treatment for in vivo stimulation techniques. Further, if optimal brain stimulation protocols are to be experimentally successful, then the heterogeneity of cortical connectivity should be accounted for in the development of those protocols and thus more spatially localized solutions may be preferable.

SUBMITTER: Taylor PN

PROVIDER: S-EPMC4453481 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature

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Optimal control based seizure abatement using patient derived connectivity.

Taylor Peter N PN Thomas Jijju J Sinha Nishant N Dauwels Justin J Kaiser Marcus M Thesen Thomas T Ruths Justin J

Frontiers in neuroscience 20150603

Epilepsy is a neurological disorder in which patients have recurrent seizures. Seizures occur in conjunction with abnormal electrical brain activity which can be recorded by the electroencephalogram (EEG). Often, this abnormal brain activity consists of high amplitude regular spike-wave oscillations as opposed to low amplitude irregular oscillations in the non-seizure state. Active brain stimulation has been proposed as a method to terminate seizures prematurely, however, a general and widely-ap ...[more]

PMID: 26089775

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Project description:Automated seizure detection is a valuable asset to health professionals, which makes adequate treatment possible in order to minimize brain damage. Most research focuses on two separate aspects of automated seizure detection: EEG feature computation and classification methods. Little research has been published regarding optimal training dataset composition for patient-independent seizure detection. This paper evaluates the performance of classifiers trained on different datasets in order to determine the optimal dataset for use in classifier training for automated, age-independent, seizure detection. Three datasets are used to train a support vector machine (SVM) classifier: (1) EEG from neonatal patients, (2) EEG from adult patients and (3) EEG from both neonates and adults. To correct for baseline EEG feature differences among patients feature, normalization is essential. Usually dedicated detection systems are developed for either neonatal or adult patients. Normalization might allow for the development of a single seizure detection system for patients irrespective of their age. Two classifier versions are trained on all three datasets: one with feature normalization and one without. This gives us six different classifiers to evaluate using both the neonatal and adults test sets. As a performance measure, the area under the receiver operating characteristics curve (AUC) is used. With application of FBC, it resulted in performance values of 0.90 and 0.93 for neonatal and adult seizure detection, respectively. For neonatal seizure detection, the classifier trained on EEG from adult patients performed significantly worse compared to both the classifier trained on EEG data from neonatal patients and the classier trained on both neonatal and adult EEG data. For adult seizure detection, optimal performance was achieved by either the classifier trained on adult EEG data or the classifier trained on both neonatal and adult EEG data. Our results show that age-independent seizure detection is possible by training one classifier on EEG data from both neonatal and adult patients. Furthermore, our results indicate that for accurate age-independent seizure detection, it is important that EEG data from each age category are used for classifier training. This is particularly important for neonatal seizure detection. Our results underline the under-appreciated importance of training dataset composition with respect to accurate age-independent seizure detection.

Project description:Analysis of long-term multichannel EEG signals for automatic seizure detection is an active area of research that has seen application of methods from different domains of signal processing and machine learning. The majority of approaches developed in this context consist of extraction of hand-crafted features that are used to train a classifier for eventual seizure detection. Approaches that are data-driven, do not use hand-crafted features, and use small amounts of patients' historical EEG data for classifier training are few in number. The approach presented in this paper falls in the latter category, and is based on a signal-derived empirical dictionary approach, which utilizes empirical mode decomposition (EMD) and discrete wavelet transform (DWT) based dictionaries learned using a framework inspired by traditional methods of dictionary learning. Three features associated with traditional dictionary learning approaches, namely projection coefficients, coefficient vector and reconstruction error, are extracted from both EMD and DWT based dictionaries for automated seizure detection. This is the first time these features have been applied for automatic seizure detection using an empirical dictionary approach. Small amounts of patients' historical multi-channel EEG data are used for classifier training, and multiple classifiers are used for seizure detection using newer data. In addition, the seizure detection results are validated using 5-fold cross-validation to rule out any bias in the results. The CHB-MIT benchmark database containing long-term EEG recordings of pediatric patients is used for validation of the approach, and seizure detection performance comparable to the state-of-the-art is obtained. Seizure detection is performed using five classifiers, thereby allowing a comparison of the dictionary approaches, features extracted, and classifiers used. The best seizure detection performance is obtained using EMD based dictionary and reconstruction error feature and support vector machine classifier, with accuracy, sensitivity and specificity values of 88.2, 90.3, and 88.1%, respectively. Comparison is also made with other recent studies using the same database. The methodology presented in this paper is shown to be computationally efficient and robust for patient-specific automatic seizure detection. A data-driven methodology utilizing a small amount of patients' historical data is hence demonstrated as a practical solution for automatic seizure detection.

Dataset Information

Optimal control based seizure abatement using patient derived connectivity.

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Optimal control based seizure abatement using patient derived connectivity.

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