Functional Connectivity-Derived Optimal Gestational-Age Cut Points for Fetal Brain Network Maturity.

ABSTRACT: The architecture of the human connectome changes with brain maturation. Pivotal to understanding these changes is defining developmental periods when transitions in network topology occur. Here, using 110 resting-state functional connectivity data sets from healthy fetuses between 19 and 40 gestational weeks, we estimated optimal gestational-age (GA) cut points for dichotomizing fetuses into 'young' and 'old' groups based on global network features. We computed the small-world index, normalized clustering and path length, global and local efficiency, and modularity from connectivity matrices comprised 200 regions and their corresponding pairwise connectivity. We modeled the effect of GA at scan on each metric using separate repeated-measures generalized estimating equations. Our modeling s

SUBMITTER: De Asis-Cruz J 

PROVIDER: S-EPMC8304646 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature