Ontology highlight
ABSTRACT:
SUBMITTER: Kwon HB
PROVIDER: S-EPMC4454280 | biostudies-literature | 2008 Dec
REPOSITORIES: biostudies-literature
Neuron 20081201 6
Presynaptic autoreceptors modulate transmitter release at many synapses. At the mossy fiber to CA3 pyramidal cell (mf-CA3) synapse, two types of glutamatergic autoreceptors have been identified: transmitter release is reportedly suppressed by metabotropic glutamate receptors (mGluRs) and augmented by kainate receptors (KARs). However, the net effect of these autoreceptors when activated by endogenous glutamate is unknown. Here, we show that during low-frequency mossy fiber stimulation, glutamate ...[more]