Ontology highlight
ABSTRACT:
SUBMITTER: Pinheiro PS
PROVIDER: S-EPMC1924597 | biostudies-literature | 2007 Jul
REPOSITORIES: biostudies-literature
Pinheiro Paulo S PS Perrais David D Coussen Françoise F Barhanin Jacques J Bettler Bernhard B Mann Jeffrey R JR Malva João O JO Heinemann Stephen F SF Mulle Christophe C
Proceedings of the National Academy of Sciences of the United States of America 20070709 29
Presynaptic ionotropic glutamate receptors are emerging as key players in the regulation of synaptic transmission. Here we identify GluR7, a kainate receptor (KAR) subunit with no known function in the brain, as an essential subunit of presynaptic autoreceptors that facilitate hippocampal mossy fiber synaptic transmission. GluR7(-/-) mice display markedly reduced short- and long-term synaptic potentiation. Our data suggest that presynaptic KARs are GluR6/GluR7 heteromers that coassemble and are ...[more]