Ontology highlight
ABSTRACT:
SUBMITTER: Liu Y
PROVIDER: S-EPMC4454296 | biostudies-literature | 2014 Aug
REPOSITORIES: biostudies-literature
Liu Y Y Zhao L L Ju Y Y Li W W Zhang M M Jiao Y Y Zhang J J Wang S S Wang Y Y Zhao M M Zhang B B Zhao Y Y
Cell death & disease 20140807
Osteosarcoma is a common primary bone tumor in children and adolescents. The drug resistance of osteosarcoma leads to high lethality. Macrophage migration inhibitory factor (MIF) is an inflammation-related cytokine implicated in the chemoresistance of breast cancer. In this study, we isolated a novel androstenedione derivative identified as 3,4-dihydroxy-9,10-secoandrosta-1,3,5,7-tetraene-9,17-dione (DSTD). DSTD could inhibit MIF expression in MG-63 and U2OS cells. The inhibition of MIF by DSTD ...[more]