Ontology highlight
ABSTRACT:
SUBMITTER: Feng T
PROVIDER: S-EPMC4454342 | biostudies-literature | 2010 Nov
REPOSITORIES: biostudies-literature
Feng Ting T Cong Yingzi Y Qin Hongwei H Benveniste Etty N EN Elson Charles O CO
Journal of immunology (Baltimore, Md. : 1950) 20101013 10
It is unknown how dendritic cells (DCs) become specialized as mucosal DCs and maintain intestinal homeostasis. We report that a subset of bone marrow cells freshly isolated from C57BL/6 mice express the retinoic acid (RA)-synthesizing enzyme aldehyde dehydrogenase family 1, subfamily A2 (ALDH1a2) and are capable of providing RA to DC precursors in the bone marrow microenvironment. RA induced bone marrow-derived DCs to express CCR9 and ALDH1a2 and conferred upon them mucosal DC functions, includi ...[more]