Pancreatic cancer patient survival correlates with DNA methylation of pancreas development genes.
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ABSTRACT:
SUBMITTER: Thompson MJ
PROVIDER: S-EPMC4454596 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Publications
Pancreatic cancer patient survival correlates with DNA methylation of pancreas development genes.
Thompson Michael J MJ Rubbi Liudmilla L Dawson David W DW Donahue Timothy R TR Pellegrini Matteo M
PloS one 20150603 6
DNA methylation is an epigenetic mark associated with regulation of transcription and genome structure. These markers have been investigated in a variety of cancer settings for their utility in differentiating normal tissue from tumor tissue. Here, we examine the direct correlation between DNA methylation and patient survival. We find that changes in the DNA methylation of key pancreatic developmental genes are strongly associated with patient survival. ...[more]
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