Ontology highlight
ABSTRACT:
SUBMITTER: Yuan X
PROVIDER: S-EPMC4454642 | biostudies-literature | 2015 Jul
REPOSITORIES: biostudies-literature
Yuan X X Shan M M You R R Frazier M V MV Hong M J MJ Wetsel R A RA Drouin S S Seryshev A A Song L-Z LZ Cornwell L L Rossen R D RD Corry D B DB Kheradmand F F
Mucosal immunology 20141203 4
Exposure to cigarette smoke can initiate sterile inflammatory responses in the lung and activate myeloid dendritic cells (mDCs) that induce differentiation of T helper type 1 (Th1) and Th17 cells in the emphysematous lungs. Consumption of complement proteins increases in acute inflammation, but the contribution of complement protein 3 (C3) to chronic cigarette smoke-induced immune responses in the lung is not clear. Here, we show that following chronic exposure to cigarette smoke, C3-deficient ( ...[more]