Dataset Information

Air pollution and atherosclerosis: a cross-sectional analysis of four European cohort studies in the ESCAPE study.

ABSTRACT:

Background

In four European cohorts, we investigated the cross-sectional association between long-term exposure to air pollution and intima-media thickness of the common carotid artery (CIMT), a preclinical marker of atherosclerosis.

Methods

Individually assigned levels of nitrogen dioxide, nitrogen oxides, particulate matter ? 2.5 ?m (PM2.5), absorbance of PM2.5 (PM2.5abs), PM10, PMcoarse, and two indicators of residential proximity to highly trafficked roads were obtained under a standard exposure protocol (European Study of Cohorts for Air Pollution Effects-ESCAPE study) in the Stockholm area (Sweden), the Ausburg and Ruhr area (Germany), and the Girona area (Spain). We used linear regression and meta-analyses to examine the association between long-term exposure to air pollution and CIMT.

Results

The meta-analysis with 9,183 individuals resulted in an estimated increase in CIMT (geometric mean) of 0.72% (95% CI: -0.65%, 2.10%) per 5-?g/m3 increase in PM2.5 and 0.42% (95% CI: -0.46%, 1.30%) per 10-5/m increase in PM2.5abs. Living in proximity to high traffic was also positively but not significantly associated with CIMT. Meta-analytic estimates for other pollutants were inconsistent. Results were similar across different adjustment sets and sensitivity analyses. In an extended meta-analysis for PM2.5 with three other previously published studies, a 0.78% (95% CI: -0.18%, 1.75%) increase in CIMT was estimated for a 5-?g/m3 contrast in PM2.5.

Conclusions

Using a standardized exposure and analytical protocol in four European cohorts, we found that cross-sectional associations between CIMT and the eight ESCAPE markers of long-term residential air pollution exposure did not reach statistical significance. The additional meta-analysis of CIMT and PM2.5 across all published studies also was positive but not significant.

SUBMITTER: Perez L

PROVIDER: S-EPMC4455580 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature

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Publications

Air pollution and atherosclerosis: a cross-sectional analysis of four European cohort studies in the ESCAPE study.

Perez Laura L Wolf Kathrin K Hennig Frauke F Penell Johanna J Basagaña Xavier X Foraster Maria M Foraster Maria M Aguilera Inmaculada I Agis David D Beelen Rob R Brunekreef Bert B Cyrys Josef J Fuks Kateryna B KB Adam Martin M Baldassarre Damiano D Cirach Marta M Elosua Roberto R Dratva Julia J Hampel Regina R Koenig Wolfgang W Marrugat Jaume J de Faire Ulf U Pershagen Göran G Probst-Hensch Nicole M NM de Nazelle Audrey A Nieuwenhuijsen Mark J MJ Rathmann Wolfgang W Rivera Marcela M Seissler Jochen J Schindler Christian C Thiery Joachim J Hoffmann Barbara B Peters Annette A Künzli Nino N

Environmental health perspectives 20150127 6

<h4>Background</h4>In four European cohorts, we investigated the cross-sectional association between long-term exposure to air pollution and intima-media thickness of the common carotid artery (CIMT), a preclinical marker of atherosclerosis.<h4>Methods</h4>Individually assigned levels of nitrogen dioxide, nitrogen oxides, particulate matter ≤ 2.5 μm (PM2.5), absorbance of PM2.5 (PM2.5abs), PM10, PMcoarse, and two indicators of residential proximity to highly trafficked roads were obtained under ...[more]

PMID: 25625785

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Dataset Information

Air pollution and atherosclerosis: a cross-sectional analysis of four European cohort studies in the ESCAPE study.

Background

Methods

Results

Conclusions

Publications

Air pollution and atherosclerosis: a cross-sectional analysis of four European cohort studies in the ESCAPE study.

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