Ontology highlight
ABSTRACT:
SUBMITTER: Hsueh PY
PROVIDER: S-EPMC4456098 | biostudies-literature | 2015 Jun
REPOSITORIES: biostudies-literature
Hsueh Pang-Yu PY Edman Maria C MC Sun Guoyong G Shi Pu P Xu Shi S Lin Yi-An YA Cui Honggang H Hamm-Alvarez Sarah F SF MacKay J Andrew JA
Journal of controlled release : official journal of the Controlled Release Society 20141216
Rapid clearance from the tears presents a formidable obstacle to the delivery of peptide drugs to the eye surface. This impedes therapies for ocular infections, wound healing, and dry-eye disease that affect the vision of millions worldwide. To overcome this challenge, this manuscript explores a novel strategy to reach the ocular surface via receptor-mediated transcytosis across the lacrimal gland (LG), which produces the bulk of human tears. The LG abundantly expresses the coxsackievirus and ad ...[more]