Ontology highlight
ABSTRACT:
SUBMITTER: Bhate MP
PROVIDER: S-EPMC4456306 | biostudies-literature | 2015 Jun
REPOSITORIES: biostudies-literature
Bhate Manasi P MP Molnar Kathleen S KS Goulian Mark M DeGrado William F WF
Structure (London, England : 1993) 20150514 6
Histidine kinases (HKs) are major players in bacterial signaling. There has been an explosion of new HK crystal structures in the last 5 years. We globally analyze the structures of HKs to yield insights into the mechanisms by which signals are transmitted to and across protein structures in this family. We interpret known enzymological data in the context of new structural data to show how asymmetry across the dimer interface is a key feature of signal transduction in HKs, and discuss how diffe ...[more]