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Chromatin immunoprecipitation of activated yeast signal transduction protein kinases

ABSTRACT: Cellular signal transduction pathways modify gene expression programs in response to changes in the environment, but the mechanisms by which they regulate populations of genes under their control are not entirely understood. We present evidence that most mitogen-activated protein kinases and protein kinase A subunits become physically associated with the genes they regulate in the yeast genome. The ability to detect this interaction of signaling kinases with target genes can be used to map more precisely and comprehensively the regulatory circuitry that eukaryotic cells use to respond to their environment.

INSTRUMENT(S): vortex

ORGANISM(S): Saccharomyces cerevisiae

SUBMITTER: Elizabeth Herbolsheimer 

PROVIDER: E-TABM-98 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Eukaryotic genomes are packaged into nucleosomes whose position and chemical modification state can profoundly influence regulation of gene expression. We profiled nucleosome modifications across the yeast genome using chromatin immunoprecipitation coupled with DNA microarrays to produce high-resolution genome-wide maps of histone acetylation and methylation. These maps take into account changes in nucleosome occupancy at actively transcribed genes and, in doing so, revise previous assessments o  ...[more]

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