Ontology highlight
ABSTRACT:
SUBMITTER: Yoshimoto FK
PROVIDER: S-EPMC4456341 | biostudies-literature | 2015 Jul
REPOSITORIES: biostudies-literature
Yoshimoto Francis K FK Auchus Richard J RJ
The Journal of steroid biochemistry and molecular biology 20141204
The steroid hydroxylation and carbon-carbon bond cleavage activities of cytochrome P450 17A1 (CYP17A1) are responsible for the production of glucocorticoids and androgens, respectively. The inhibition of androgen synthesis is an important strategy to treat androgen-dependent prostate cancer. We discuss the different enzymatic activities towards the various substrates of CYP17A1, demonstrating its promiscuity. Additionally, a novel interhelical interaction is proposed between the F-G loop and the ...[more]