Ontology highlight
ABSTRACT:
SUBMITTER: Burris-Hiday SD
PROVIDER: S-EPMC8087655 | biostudies-literature | 2021 May
REPOSITORIES: biostudies-literature
Burris-Hiday Sarah D SD Scott Emily E EE
Molecular and cellular endocrinology 20210326
Cytochrome P450 17A1 (CYP17A1) is a critical steroidogenic enzyme, essential for producing glucocorticoids and sex hormones. This review discusses the complex activity of CYP17A1, looking at its role in both the classical and backdoor steroidogenic pathways and the complex chemistry it carries out to perform both a hydroxylation reaction and a carbon-carbon cleavage, or lyase reaction. Functional and structural investigations have informed our knowledge of these two reactions. This review focuse ...[more]