Unknown

Dataset Information

0

PARP inhibitors and more.

ABSTRACT: Polyadenosine diphosphate (ADP) ribose polymerase (PARP) lends a panoramic view to the inner mystery of protection of integrity of deoxyribonucleic acid (DNA) in a cell genome. They are a balancing part of an even more dynamic equilibrium of normalcy against daily assaults. PARP finds its companion candidates in other tumor suppressors, with the most prominent and glaring one being breast cancer (BRCA) 1 and 2. The strength of both is split by PARP inhibitors, inculcating the synthetic lethality of tumor cell, which is now in the market for ovarian cancer treatment. There are many reasons for the resistance of such inhibitors, which are now becoming clinically important. These are seen along with other damage repair approaches.

SUBMITTER: Bose CK 

PROVIDER: S-EPMC4456968 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

PARP inhibitors and more.

Bose Chinmoy K CK   Basu Nirban N  

Journal of the Turkish German Gynecological Association 20150601 2

Polyadenosine diphosphate (ADP) ribose polymerase (PARP) lends a panoramic view to the inner mystery of protection of integrity of deoxyribonucleic acid (DNA) in a cell genome. They are a balancing part of an even more dynamic equilibrium of normalcy against daily assaults. PARP finds its companion candidates in other tumor suppressors, with the most prominent and glaring one being breast cancer (BRCA) 1 and 2. The strength of both is split by PARP inhibitors, inculcating the synthetic lethality  ...[more]

Similar Datasets

Unknown Reverse the Resistance to PARP Inhibitors.
| S-EPMC5332874 | biostudies-other
Unknown PARP Inhibitors in Pancreatic Cancer.
| S-EPMC8682800 | biostudies-literature
Unknown Advances and perspectives of PARP inhibitors.
| S-EPMC6849303 | biostudies-literature
Unknown PARP inhibitors in metastatic prostate cancer.
| S-EPMC10165068 | biostudies-literature
Unknown PARP Inhibitors Resistance: Mechanisms and Perspectives.
| S-EPMC8945953 | biostudies-literature
Unknown PARP goes the weasel! Emerging role of PARP inhibitors in acute leukemias.
| S-EPMC9295907 | biostudies-literature
Unknown Advances in using PARP inhibitors to treat cancer.
| S-EPMC3312820 | biostudies-other
Unknown The Synergistic Effect of PARP Inhibitors and Immune Checkpoint Inhibitors.
| S-EPMC7934064 | biostudies-literature
Unknown PARP inhibitors: Synthetic lethality in the clinic.
| S-EPMC6175050 | biostudies-literature
Unknown Update on PARP Inhibitors in Breast Cancer.
| S-EPMC7430202 | biostudies-literature