Ontology highlight
ABSTRACT:
SUBMITTER: Choi SK
PROVIDER: S-EPMC4457390 | biostudies-literature | 2012 Apr
REPOSITORIES: biostudies-literature
Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology 20120111 4
Nanoparticle (NP)-based targeted drug delivery involves cell-specific targeting followed by a subsequent therapeutic action from the therapeutic carried by the NP system. NPs conjugated with methotrexate (MTX), a potent inhibitor of dihydrofolate reductase (DHFR) localized in cytosol, have been under investigation as a delivery system to target cancer cells to enhance the therapeutic index of methotrexate, which is otherwise non-selectively cytotoxic. Despite improved therapeutic activity from M ...[more]