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Generation 3 PAMAM dendrimer TAMRA conjugates containing precise dye/dendrimer ratios.

ABSTRACT: The synthesis, isolation, and characterization of generation 3 poly(amidoamine) (G3 PAMAM) dendrimer containing precise ratios of 5-carboxytetramethylrhodamine succinimidyl ester (TAMRA) dye (n = 1-3) per polymer particle are reported. Stochastic conjugation of TAMRA dye to the dendrimer was followed by separation into precise dye-polymer ratios using rp-HPLC. The isolated materials were characterized by rp-UPLC, MALDI-TOF-MS, and 1H NMR spectroscopy, UV-vis, and fluorescence spectroscopies.

SUBMITTER: Manono J 

PROVIDER: S-EPMC4631223 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature

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Generation 3 PAMAM dendrimer TAMRA conjugates containing precise dye/dendrimer ratios.

Manono Janet J   Dougherty Casey A CA   Jones Kirsten K   DeMuth Joshua J   Holl Mark M Banaszak MM   DiMaggio Stassi S  

Materials today (Kidlington, England) 20150609

The synthesis, isolation, and characterization of generation 3 poly(amidoamine) (G3 PAMAM) dendrimer containing precise ratios of 5-carboxytetramethylrhodamine succinimidyl ester (TAMRA) dye (<i>n</i> = 1-3) per polymer particle are reported. Stochastic conjugation of TAMRA dye to the dendrimer was followed by separation into precise dye-polymer ratios using rp-HPLC. The isolated materials were characterized by rp-UPLC, MALDI-TOF-MS, and <sup>1</sup>H NMR spectroscopy, UV-vis, and fluorescence s  ...[more]

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