Ontology highlight
ABSTRACT:
SUBMITTER: Paciolla M
PROVIDER: S-EPMC4457537 | biostudies-literature | 2015 Jun
REPOSITORIES: biostudies-literature
Paciolla M M Pescatore A A Conte M I MI Esposito E E Incoronato M M Lioi M B MB Fusco F F Ursini M V MV
Genes and immunity 20150312 4
Mendelian primary immunodeficiency diseases (MPIDs) are rare disorders affecting distinct constituents of the innate and adaptive immune system. Although they are genetically heterogeneous, a substantial group of MPIDs is due to mutations in genes affecting the nuclear factor-κB (NF-κB) transcription pathway, essential for cell proliferation and cell survival and involved in innate immunity and inflammation. Many of these genes encode for crucial regulatory components of the NF-κB pathway and th ...[more]